Our Research Members

Mark R. Palmert
Palmert, Mark R.
MD, PhD
U Of T Appointments

Associate Professor, Department of Pediatrics and Physiology

Other Appointments

Senior Associate Scientist, Genetics & Genome Biology Program, Hospital For Sick Children

Contact Information
The Hospital for Sick Children
555 University Avenue
Toronto, ON M5G 1X8
Phone: 416-813-6217
Fax: 416-813-6304
mark.palmert@sickkids.ca
Diabetes Related Research Activities:

I care for children and adolescents with type 1 and type 2 diabetes mellitus. I have been involved in diabetes related clinical research as a Principal Investigator in the NIH multicentered trial entitled Treatment Options for Type 2 Diabetes in adolescents and Youth (TODAY), which was designed to identify best ways to treat type 2 diabetes in youth. I have also been Principal Investigator the Clinical Coordinating Center for the NIH/NIDDK funded Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC).
Currently, my diabetes related research includes membership in the Hvidoere Study Group of Childhood Diabetes and using technology to enhance diabetes self-management. We and collaborators are performing a randomized clinical trial designed to test an iPhone based system to help adolescents manage their diabetes more effectively.

I addition to these clinical research activities, I also direct lab-based research investigating the effects that in utero exposures on adult outcomes, such as development of diabetes and abnormalities of bone and metabolism.

Esteban J. Parra
Parra, Esteban J.
PhD
U Of T Appointments

Associate Professor, Department of Anthropology

Contact Information
University of Toronto at Mississauga, Room 352 Health Sciences Complex
3359 Mississauga Road North
Mississauga, ON L5L 1C6
Phone: 905-828-3889
Fax: 905-828-3792
esteban.parra@utoronto.ca
View website
Diabetes Related Research Activities:

Type 2 diabetes is one of the most serious public health issues in Canada and on a global scale. There are striking differences in prevalence among ethnic groups. The prevalence of type 2 diabetes among Aboriginal people is higher than in the general population, and elevated risk has also been described for other groups, such as Hispanics. One of the major goals of Dr. Parra’s research is to identify type 2 diabetes genetic risk factors in Hispanic populations, using different approaches, such as candidate gene studies, admixture mapping and genome-wide association.

Monica Parry
Parry, Monica
MEd MSc PhD
U Of T Appointments

Assistant Professor
Leadership Team
Director, Nurse Practitioner Programs
Lawrence S. Bloomberg Faculty of Nursing

Other Appointments

Nurse Practitioner – Adult, Cardiac Surgery, Kingston General Hospital

Contact Information
Suite 130
155 College Street
Toronto, ON M5T 1P8
Phone: 416-946-3561
Fax: 416-978-8222
monica.parry@utoronto.ca
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Diabetes Related Research Activities:

I have worked as a Nurse Practitioner in Cardiac Surgery since 1998, and in my role have cared for many individuals with diabetes (T2DM). Many patients who have sternal wound infections have diabetes, and many individuals have poor blood sugar control following cardiac surgery. Collaborating with an Endocrinilogist I helped to develop standardized pre-printed orders to help manage blood sugars for our patient’s who had T2DM. I am interested in the prevention of complications in individuals with diabetes, with a specific interest is in the prevention of cardiovascular disease. I am a co-investigator and member of the steering committee for a CIHR-funded team grant (PI Dr. Stewart Harris) investigating diabetes in several aboriginal communities in Canada. Current efforts are directed to the detection of autonomic neuropathies using impedance cardiography.

Andrew D. Paterson
Paterson, Andrew D.
MB ChB, BSc(Hons)
U Of T Appointments

Associate Professor, Dalla Lana School of Public Health

Other Appointments

Senior Scientist, Program in Genetics and Genome Biology, Hospital for Sick Children

Contact Information
Hospital For Sick Children Research Institute
686 Bay St., PGCRL Rm 12.9835
Toronto, ON M5G 0A4
Phone: 416-813-6994
Fax: 416-813-2150
andrew.paterson@utoronto.ca
View website
Diabetes Related Research Activities:

Long-term complications of diabetes, including eye and kidney disease cluster in families suggesting that genetic factors may be involved. Using DNA from large numbers of people with diabetes who have their complications measured, we are using high throughput methods to measure all of the common genetic variation in the human genome to identify which ones are associated with specific complications. In addition, we are identifying genetic loci that are associated with the major risk factors for diabetes complications – glycemia, blood pressure, body composition and lipids.

Bruce Perkins
Perkins, Bruce
MD
U Of T Appointments

Assistant Professor, Department of Medicine, Division of Endocrinology and Metabolism

Other Appointments

Staff Physician, University Health Network

Contact Information
Mount Sinai Hospital
60 Murray Street, Room L5-210
Toronto, ON M5T 3L9
Phone: 416-586-8763
Bruce.Perkins@sinaihealthsystem.ca
Diabetes Related Research Activities:

My research initiatives focus on using epidemiological techniques to explore the natural history of diabetes complications and novel strategies for their prevention. My major clinical research areas include:
Characterizing the natural history of diabetic polyneuropathy and defining the best methods for clinical assessment.
Exploring the pattern of renal function decline and its determinants early in the course of nephropathy in type 1 diabetes.
Diabetes technologies, including the process of care for intensive insulin therapy.

Dana Philpott
Philpott, Dana
PhD
U Of T Appointments

Associate Professor, Faculty of Medicine, Department of Immunology

Contact Information
Medical Sciences Building, Room 7318
1 King's College Circle
Toronto, ON M5S 1A8
Phone: 416-978-7527
dana.philpott@utoronto.ca
Diabetes Related Research Activities:

We are interested in the role of innate immunity, specifically Nod like receptors, as well as the microbiota in diabetes pathogenesis.

Philippe Poussier
Poussier, Philippe
MD
U Of T Appointments

Associate Professor, Department of Medicine, Division of Endocrinology and Metabolism, and Department of Immunology

Contact Information
Sunnybrook Health Science Centre Research Institute
2075 Bayview Avenue, Room A3.38
Toronto, ON M4N 3M5
Phone: 416-480-6136
Fax: 416-480-4375
philippe.poussier@sri.utoronto.ca
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Diabetes Related Research Activities:

The objective of our research program is to identify type 1 diabetes (T1D) susceptibility genes in the spontaneously diabetic BB rat, and to characterize the immune mechanisms underlying allelic variation at these susceptibility loci. In particular, we are focusing on genes that appear to be shared between humans and the BB rat. These genetic studies combine linkage analyses, development and characterization of congenic and mutant lines of animals, transfected cell lines. We are also studying the role of differential colonization of the intestine by commensal bacteria on the development of antipancreatic autoimmunity with the objective to understand how environmental changes can affect the expression of diabetogenic genotypes. Another topic of research using transgenic murine models of type 1 diabetes is the characterization of the molecular mechanisms involved in the homing of diabetogenic T cells to pancreatic islets.

Gérald J. Prud'homme
Prud'homme, Gérald J.
MD, FRCPC
U Of T Appointments

Professor, Department of Laboratory Medicine and Pathobiology

Other Appointments

Clinician-Scientist, St. Michael’s Hospital

Contact Information
St. Michael's Hospital
30 Bond St.
Toronto, ON M5B 1W8
Phone: 416-864-6060 x3147
prudhommeg@smh.ca
View website
Diabetes Related Research Activities:

Research in my laboratory focuses on the immunology of type 1 diabetes, and the development of new drugs and therapies for diabetes. We are studying some key molecules involved in immunopathological diseases, including transforming growth factor beta, neuropilin and the aryl hydrocarbon receptor. This work requires the application of a wide variety of immunological, molecular biological and biochemical techniques, in relevant disease models.