Our Research Members

Jayne Danska
Danska, Jayne
U Of T Appointments

Professor, Department of Immunology; Department of Medical Biophysics

Other Appointments

Senior Scientist, Genetics and Genome Biology
Anne and Max Tanenbaum Chair in Molecular Medicine
Associate Chief, Faculty Development and Diversity
Hospital for Sick Children Research Institute

Contact Information
Peter Gilgan Centre for Research and Learning
686 Bay Street
Toronto, ON M5G 0A4
Phone: 416-813-8810
jayne.danska@sickkids.ca
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Diabetes Related Research Activities:

The focus of Dr. Danska’s research is defining mechanisms of immune mediated diseases and application of this knowledge to improve their diagnosis, prevention and treatment.  Her lab works on the genetic and environmental causes of autoimmune disease, particularly Type 1 diabetes (T1D) in animal models and prospective human cohort studies. Her group found that manipulation of the intestinal microbial community (microbiome) strongly influences levels of sex hormone levels, host metabolites and can protect mice with high inherited risk from T1D.  She has led international projects that identified diabetes risk genes and determined how these variants control immune pathogenesis.  Her current work is focused on identification of environmental factors responsible for the rise in rates of autoimmune and inflammatory diseases, and how these factors are modified by the intestinal microbiome. She has a long-standing interest in sex as a determinant of autoimmune disease risk and pathogenesis.

Satya Dash
Dash, Satya
MD, PhD, FRCP (Edin), FRCPC
U Of T Appointments

Assistant Professor, Department of Medicine

Other Appointments

Staff Physician, Division of Endocrinology, Toronto General Hospital
Medical Director, Bariatric Programme, University Health Network

Contact Information
Toronto General Hospital
Eaton Building, 12EN-213
200 Elizabeth St.
Toronto, ON M5G 2C4
Phone: 416-340-4800 x8094
Fax: 416-340-3314
satya.dash@uhn.ca
Diabetes Related Research Activities:

I am interested in obesity and insulin resistance. More specifically I aim to assess the role of the central nervous system in mediating various metabolic processes in humans in responses to drugs and peptides. Another avenue of research I will explore is investigating the etiology of obesity, its metabolic complications and response to treatment. I aim to utilize a combination of integrative in vivo physiology, genetic and pharmacological approaches to answer these research questions with the ultimate aim of potentially developing novel therapies for metabolic disorders.

Charles de Mestral
de Mestral, Charles
MD, PhD
U Of T Appointments

Assistant Professor (status), Institute for Health Policy, Management and Evaluation

Other Appointments

Vascular Surgeon, St. Michael’s Hospital
Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
Adjunct Scientist, Institute for Clinical Evaluative Sciences

Contact Information
St. Michael's Hospital
Bond 7-073
30 Bond Street
Toronto, ON M5B 1X1
Phone: 416-864-6047
Fax: 416-864-6012
Charles.deMestral@unityhealth.to
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Diabetes Related Research Activities:

I pursue population-based health services research focusing on patients with diabetes who undergo lower limb amputation. I am interested in better characterizing the epidemiology, outcomes, health-resource use and costs of lower limb amputation in diabetic patients as well as limb preservation therapies. The purpose of this work is to inform population-level interventions to reduce diabetes-related foot complications.

Daniel J. Drucker
Drucker, Daniel J.
MD, FRCPC
U Of T Appointments

Professor, Department of Medicine, Division of Endocrinology & Metabolism

Other Appointments

Senior Scientist, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

Contact Information
Mt. Sinai Hospital
University of Toronto
Lunenfeld Tanenbaum Research Institute
Toronto, ON M5G 1X5
Phone: 416-361-2661
drucker@lunenfeld.ca
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Diabetes Related Research Activities:

Research in the Drucker lab is focused on understanding the biology of gut hormones, with a major focus on GIP and the glucagon-like peptides. The lab studies how glucagon, GIP, GLP-1, and GLP-2 regulate energy homeostasis, metabolic control, and cardiovascular function via effects on the gastrointestinal tract, pancreas, cardiovascular system and central nervous system. Specific projects elucidate novel mechanisms of glucagon, GIP, GLP-1 and GLP-2 action through studies of their respective receptors in peripheral tissues. Research staff utilize a combination of techniques that involve studies of signal transduction, generation of transgenic or knockout mice, and studies of rodent models of peptide hormone action with a focus on diabetes, obesity, endocrine systems, and intestinal disease.

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