Our Research Members

Jayne Danska
Danska, Jayne
U Of T Appointments

Professor, Department of Immunology; Department of Medical Biophysics

Other Appointments

Program in Genetics and Genome Biology, Hospital for Sick Children

Contact Information
MaRS, East Tower, Room 14-313
101 College Street
Toronto, ON M5G 1L7
Phone: 416-813-8810
Fax: 416-813-8823
jayne.danska@sickkids.ca
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Diabetes Related Research Activities:

The objective of our research program is to define the genetic and environmental factors driving autoimmune mediated targeting of islet cells and to use this information to design and test therapeutics that prevent, block progression of or reverse type 1 diabetes. We have taken a multidisciplinary approach to genetic, genomic and immunological analysis of T1D risk in a well-validated mouse models, focusing on dissection of the complex genetics to provide insight into human T1D pathogenesis. We have extended these studies of the role of sex and of intestinal commensal bacteria on modifying genetic risk, and application of discoveries in rodent models to large, prospective cohort study of environmental determinants of T1D in genetically at risk children.

Satya Dash
Dash, Satya
MD, PhD, FRCPC, MRCP(UK)
U Of T Appointments

Assistant Professor, Department of Medicine, Division of Endocrinology and Metabolism

Other Appointments

Staff Physician, University Health Network/Mount Sinai Hospital

Contact Information
Toronto General Hospital
200 Elizabeth St., Eaton Building, 12EN
Toronto, ON M5G 2C4
Phone: 416-340-4800 x8094
satya.dash@uhn.ca
Diabetes Related Research Activities:

I am interested in obesity and insulin resistance. More specifically I aim to assess the role of the central nervous system in mediating various metabolic processes in humans in responses to drugs and peptides. Another avenue of research I will explore is investigating the etiology of obesity, its metabolic complications and response to treatment. I aim to utilize a combination of integrative in vivo physiology, genetic and pharmacological approaches to answer these research questions with the ultimate aim of potentially developing novel therapies for metabolic disorders.

Margaret De Melo
De Melo, Margaret
BSc, RD, CDE
Other Appointments

Practice Leader-Clinical Nutrition, Allied Health, University Health Network

Contact Information
Toronto Western Hospital
399 Bathurst Street, 1WW443
Toronto, ON M5T 2S8
Phone: 416-603-5800 x5973
Fax: 416-603-5210
margaret.demelo@uhn.ca
Diabetes Related Research Activities:

I am interested in research that focuses on diabetes self-care management (DSM).

As part of interprofessional research teams, I have studied the effectiveness of DSM education programs, utilization and attrition such programs, food insecurity in Canadians with diabetes, and gender differences, psychosocial and clinical factors that help us better understand and serve those affected by diabetes.

Charles de Mestral
de Mestral, Charles
MD, PhD
U Of T Appointments

Assistant Professor, Department of Surgery

Other Appointments

Vascular Surgeon, St. Michael’s Hospital
Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
Adjunct Scientist, Institute for Clinical Evaluative Sciences

Contact Information
St. Michael's Hospital
30 Bond Street, Bond 7-073
Toronto, ON M5B 1X1
Phone: 416-864-6047
Fax: 416-864-6012
deMestralCh@smh.ca
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Diabetes Related Research Activities:

I pursue population-based health services research focusing on patients with diabetes who undergo lower limb amputation. I am interested in better characterizing the epidemiology, outcomes, health-resource use and costs of lower limb amputation in diabetic patients as well as limb preservation therapies. The purpose of this work is to inform population-level interventions to reduce diabetes-related foot complications.

Daniel J. Drucker
Drucker, Daniel J.
MD, FRCPC
U Of T Appointments

Professor, Department of Medicine, Division of Endocrinology & Metabolism

Other Appointments

Senior Scientist, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital

Contact Information
Mount Sinai Hospital TCP 5-1004
600 University Ave.
Toronto, ON M5G 1X5
Phone: 416-361-2661
Fax: 416-361-2669
drucker@lunenfeld.ca
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Diabetes Related Research Activities:

Research in the Drucker lab is focused on understanding the biology of gut hormones, with a major focus on GIP and the glucagon-like peptides. The lab studies how glucagon, GIP, GLP-1, and GLP-2 regulate energy homeostasis, metabolic control, and cardiovascular function via effects on the gastrointestinal tract, pancreas, cardiovascular system and central nervous system. Specific projects elucidate novel mechanisms of glucagon, GIP, GLP-1 and GLP-2 action through studies of their respective receptors in peripheral tissues. Research staff utilize a combination of techniques that involve studies of signal transduction, generation of transgenic or knockout mice, and studies of rodent models of peptide hormone action with a focus on diabetes, obesity, endocrine systems, and intestinal disease.