Our Research Members

Andras Nagy
Nagy, Andras
PhD
U Of T Appointments

Professor, Department of Obstetrics & Gynaecology and Institute of Medical Sciences

Other Appointments

Senior Investigator, Lunenfeld-Tanenbaum Research Institute
Tier 1 Canada Research Chair in Stem Cells and Regeneration

Contact Information
Lunenfeld-Tanenbaum Research Institute
60 Murray Street, Box 40
Toronto, ON M5T 3L9
Phone: 416-586-4800 x53614165868
Fax: 416-586-5130
nagy@lunenfeld.ca
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Diabetes Related Research Activities:

Somatic cell reprogramming to induced pluripotent stem cells requires the expression of 2-4 key transcription factors. We have demonstrated that the piggyBac transposon-based transgene delivery system combined with tetracycline inducible gene expression can be used to reprogram cells with a comparably high efficiency to viral transduction, both from mouse and human somatic cells. Unique properties of our transposon-based system form the foundation for exploring the plasticity of the ß-cell. Using a transgenic reprogrammable mouse line, we are exploring the possibility expanding, differentiating and trans-differentiating cells of the pancreatic lineage in a whole organism context and ex vivo. T his research aims to take a giant leap forward in the understanding of the cellular plasticity of ß-cells and the development of novel tools for bringing efficient cell-based therapies to the future of medicine.

Paul C. Nathan
Nathan, Paul C.
MD, MSc
U Of T Appointments

Professor, Department of Paediatrics, Division of Haematology/Oncology

Other Appointments

Associate Scientist, Hospital for Sick Children Research Institute

Contact Information
The Hospital for Sick Children
555 University Avenue
Toronto, ON M5G 1X8
Phone: 416-813-8795
Fax: 416-813-5327
paul.nathan@sickkids.ca
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Diabetes Related Research Activities:

Dr. Nathan’s research focuses on long-term outcomes in survivors of childhood cancer. His interests include obesity and other metabolic sequelae of cancer treatment, as well as cardiac outcomes in children treated with cardiotoxic chemotherapy or radiation. In addition, he is interested in health care utilization and screening/surveillance late effects in adult survivors of childhood cancer.

Dominic S. Ng
Ng, Dominic S.
PhD, MD, FRCPC
U Of T Appointments

AssociateProfessor, Department of Medicine, Division of Endocrinology & Metabolism; Department of Physiology and Department of Laboratory Medicine and Pathobiology

Other Appointments

Scientist, Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael’s Hospital

Contact Information
St. Michael's Hospital
30 Bond Street, Shuter Wing, 3rd Floor, Room 3-041
Toronto, ON M5B 1W8
Phone: 416-864-5197
Fax: 416-864-5584
ngd@smh.ca
Diabetes Related Research Activities:

My research lab is primarily interested in the area of genetics of lipid disorders and cardio-metabolic disorders with special emphasis on high density lipoprotein (HDL) metabolism. We use transgenic/knock out mice as models and our tools include in vivo experiments, ex vivo and in vitro assays at tissue, cellular, and molecular levels. We are particularly interested in using in vivo mouse models to examine the impact of specific genetic-based dyslipidemic states on atherogenesis, diabetogenesis and more recently, obesity and brown fat development. Detailed analyses of these animal models using cellular, molecular and genetic markers will also be carried out to elucidate the underlying mechanism of such disease processes and their interactions. Such genetic models are also used to study the effects of dietary and drug interventions.

Maria Cristina Nostro
Nostro, Maria Cristina
PhD
U Of T Appointments

Assistant Professor, Department of Physiology

Other Appointments

Harry Rosen Chair in Diabetes and Regenerative Medicine Research, McEwen Centre for Regenerative Medicine
Scientist, Division of Experimental Therapeutics, Toronto General Research Institute, UHN

Contact Information
MaRS Centre, Room 3-918
101 College St
Toronto, ON M5G 1L7
Phone: 416-581-7595
Fax: 416-581-7606
cnostro@uhnresearch.ca
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Diabetes Related Research Activities:

– Generation of pancreatic beta cells from human pluripotent stem cells
– Cell therapy for type I diabetes
– Modeling lineage commitment and human development in vitro
– Using human pluripotent stem cell-derived pancreatic cells as a platform for drug screening

Sara Nunes Vasconcelos
Nunes Vasconcelos, Sara
PhD
U Of T Appointments

Assistant Professor, Institute of Biomaterials and Biomedical Engineering
Laboratory of Medicine and Pathobiology

Other Appointments

Assistant Scientist, Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network
Member of the Heart & Stroke/Richard Lewar Centre of Excellence (HSRLCE), University of Toronto
Member of Ontario Institute for Regenerative Medicine (OIRM)

Contact Information
TMDT 3-904
101 College St.
Toronto, ON M5G 1L7
Phone: 416-581-7527
sara.vasconcelos@utoronto.ca
Diabetes Related Research Activities:

We are investigating how diabetes affects vessel formation (angiogenesis and arterio-venous specification) and its implications in tissue engineering for regenerative medicine. Moreover, we are investigating the direct effects of diabetes and diabetes-related drugs on crdiovascular health including human stem cell-derived cardiomyocyte organoid models.