Research in my laboratory focuses on the immunology, pathogenesis and therapy of type 1 diabetes. We are investigating drugs that can induce the regeneration of pancreatic beta cells, or prevent beta-cell death.  This includes studies of GABA, GLP-1, Klotho, TGF-beta inhibitors, and other molecules or drugs relevant to diabetes therapy. In many cases, human pancreatic islets are transplanted into immunodeficient cells for in vivo studies. This work requires the application of a wide variety of immunological, biochemical, cellular and molecular biological techniques, in relevant disease models.