Our laboratory is interested in the identification and characterization of circulating factors influencing beta cell function during the pathogenesis of diabetes. Utilizing a combination of animal models, human patient samples, primary tissues, clonal cell lines, and molecular biology approaches, we aim to interrogate how inter-organ communication via proteins and metabolites is altered early in the development of both type 1 and type 2 diabetes, contributing to the overt manifestation of disease. Ultimately, we hope to identify novel biomarkers and therapeutic targets that can be harnessed to prevent or delay diabetes development.