Research in the Cummins lab relates to the study of nuclear hormone receptors that are important in the control of glucose and lipid metabolism. Our lab is interested in all areas of nuclear receptor biology including the identification of new ligands; the study of signaling pathways upstream and downstream of receptor activation; the characterization of novel co-regulatory proteins; and the influence of nuclear receptor modulation on whole animal physiology. Our studies primarily investigate the importance of the glucocorticoid receptor (GR), the liver X receptor  (LXRα and LXRβ) and the peroxisome proliferator activated receptor (PPARα, PPARδ and PPARγ) signaling pathways in the context of diabetes and dyslipidemia.