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Rocheleau, Jonathan V. - PhD

University of Toronto Appointment(s): Associate Professor, Institute of Biomaterials and Biomedical Engineering; Department of Medicine; Department of Physiology

Other Appointment(s): Affiliated Scientist, Toronto General Research Institute, University Health Network

Contact Information:

MaRS Centre, Toronto Medical Discovery Tower
101 College Street
10th Floor, Room 10-707
Toronto , Ontario M5G 1L7

Phone: 416-581-7839
Fax: 416-581-7839

Diabetes Related Research Activities:

Interaction between pancreatic islets and vascular endothelial cells is necessary for the maintenance of beta-cell mass and function. Aside from acting as a conduit for molecular oxygen, vascular endothelial cells in vivo secrete the majority of islet extracellular matrix (ECM). This ECM likely provides a permissive signal for beta-cell proliferation, contributing to the coordinated hyperplasia of these tissues during the early stages of Type 2 diabetes. This ECM also provides a reservoir for heparin binding growth factors that further modulate this hyperplasia, including fibroblast growth factor (FGF) and vascular endothelial growth factor-A (VEGF-A). We hypothesize that communication between beta-cells and vascular endothelial cells directs the proliferation and function of both tissues.

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