Darren Yuen
Yuen, Darren MD, PhD
U Of T Appointments

Assistant Professor, Temerty Faculty of Medicine

Other Appointments

Staff Physician, Division of Nephrology, St. Michael’s Hospital
Scientist, Li Ka Shing Knowledge Institute

Contact Information
St. Michael's Hospital
Li Ka Shing Knowledge Institute
209 Victoria St.
Toronto, ON M5B 1T8
Phone: 416-864-6060 x77366
Fax: 416-867-3654
[email protected]
View website
Diabetes Related Research:
My research program is focussed on the development of novel therapies targeting the fibrosis and endothelial injury that occurs in the diabetic kidney. As a nephrology clinician scientist at St. Michael’s Hospital, my research involves the use of both cell biology and animal models of diabetic injury. Current work in the lab is devoted to understanding: (1) mechanisms of diabetic endothelial injury, including both the early glomerular angiogenesis and the later capillary rarefaction that occurs in diabetes, (2) novel mechanisms of fibroblast activation in diabetes, including the relevance of fibroblast cytoskeletal rearrangements in this process, and (3) the effects of diabetes on podocyte structure and function.