Profiles of BBDC Members Primarily Involved In Diabetes Research

Search for Name or Keyword

ABCDEFGHIJKLMNOPRSvWYZ All


Fraser, Paul E. - PhD

University of Toronto Appointment(s): Professor, Department of Medical Biophysics
Senior Scientist, Tanz Centre for Research in Neurodegenerative Diseases

Contact Information:
Krembil Discovery Tower
60 Leonard Street
Toronto, ON   M5T 2S8

Phone: 416 507-6848
Fax: 416 507-6435
Email: paul.fraser@utoronto.ca
Websites: http://medbio.utoronto.ca/faculty/fraser.html

Diabetes Related Research Activities:

Increasing evidence now points to the deposition and cytotoxicity of islet amyloid polypeptide aggregates as major contributors to loss of beta cell mass and ultimately the progression to type 2 diabetes. Amyloid aggregation may also contribute to graft failure following islet transplantation in type 1 diabetes patients. Therefore, our research involves devising new ways to inhibit islet amyloid aggregation and protect beta cells, thereby slowing or preventing onset of type 2 diabetes and improving islet graft survival.

View Publications


Fu, Lei - PhD, DABCC, FACB, FCACB

University of Toronto Appointment(s): Assistant Professor, Department of Laboratory Medicine & Pathobiology

Other Appointment(s): Clinical Biochemist, Department of Clinical Pathology, Sunnybrook Health Sciences Centre

Contact Information:
Room B204
2075 Bayview Ave
Toronto, ON   M4N 3M5

Phone: 416-480-6100 Ext: 89571
Fax: 416-480-6035
Email: lei.fu@sunnybrook.ca

Diabetes Related Research Activities:

To study the molecular relationship between vitamin D endocrine system and diabetes.

View Publications


Gaisano, Herbert Y. - MD, FRCPC, FACP

University of Toronto Appointment(s): Professor, Departments of Medicine and Physiology

Contact Information:

University of Toronto
1 King's College Circle
Medical Sciences Building, Rooms 7358 and 7368
Toronto, Ontario, M5S 1A8

Phone: 416-978-1526
Fax: 416-978-8765
Email: herbert.gaisano@utoronto.ca

Diabetes Related Research Activities:

Research in the Gaisano lab is focused on molecular mechanisms regulating exocytosis, employing islet cells as models. We were one of the firsts to demonstrate that SNARE proteins originally found to mediate neurotransmitter release are conserved in non-neuronal cells, including the pancreatic islet to regulate secretion. We contributed to the original work showing SNARE protein regulation of insulin granule exocytosis, and subsequently contributed much of the work showing how SNARE proteins physically and functionally interact with beta-cell ion channels (Kv, KATP, Ca2+) to regulate the intricate sequence of ion fluxes, membrane potential and exocytotic fusion events leading to secretion. Current efforts are directed at: 1) SNARE proteins regulation of newcomer granule exocytosis and compound insulin granule fusion, and employing such molecules by viral gene transfer to rescue type 2 diabetes; 2) excitosome formation of SNAREs with Kv and Ca2+ channels during insulin granule docking and priming; and 3) islet alpha cell secretory mechanisms and crosstalk with beta- and delta-cells in health and their dysregulation in diabetes. This lab has in place a full spectrum of state-of-the-art single islet cell analyses for rodent and human islets, including patch clamp electrophysiology and capacitance measurements on dispersed cells and intact islets within pancreas slices, imaging of single granule exocytosis by TIRFM, single islet cell (beta, alpha and delta cells) imaging within whole islet by confocal and multi-photon microscopy, and high-resolution FRET analysis of molecular interactions.

This lab also has full capabilities to perform assays for in vivo glucose homeostasis, including glucose clamps and surgical pancreatic duct perfusion of viruses for in vivo rescue of diabetic rodent models; islet cell biology assays, including islet isolation, islet perifusion secretory assays, assessment of intact islets within pancreatic slices in diabetic models, E.M.; biochemistry (immunoprecipitation), molecular biology and viral gene transfer (adeno/AAV/lentivirus).

View Publications


Giacca, Adria

University of Toronto Appointment(s): Professor, Department of Physiology and Department of Medicine

Other Appointment(s):  
 
 

Contact Information:

University of Toronto, Medical Sciences Building
1 King's College Circle, Room 3336
Toronto, Ontario M5S 1A8

Phone: 416-978-0167
Fax: 416-978-4373
Email: adria.giacca@utoronto.ca
Websites: http://www.physiology.utoronto.ca/content/adria-giacca

Diabetes Related Research Activities:

The primary theme of A.G.'s research is the investigation of the effects of excess circulating energy substrates, in particular free fatty acids, on insulin action, secretion and kinetics, and the implication of these effects for the pathogenesis of diabetes. Secondary themes of research are the studies of the effects of nutrient and insulin excess in animal models of atherosclerosis and cancer .

View Publications


Gilbert, Richard E. - MD, PhD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine

Other Appointment(s): Head, Division of Endocrinology & Metabolism, St. Michael's Hospital
Canada Research Chair in Diabetes Complications

Contact Information:
61 Queen Street East
Toronto, ON   M5C 2T2

Phone: 416-867-3747
Email: richard.gilbert@utoronto.ca
Websites: http://stmichaelshospitalresearch.ca/researchers/richard-e-gilbert/

Diabetes Related Research Activities:

Research in the Gilbert lab focuses on the pathogenesis of diabetes complications as a way to evolve new therapies to prevent their development and attenuate their progression. Current projects involve translational research in diabetic nephropathy, retinopathy and heart failure, exploring novel  pharmacological treatments and the use of adult stem cells to regenerate diseased tissue.

View Publications



Records 36 to 40 of 132
<< < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 > >> page(s)