Profiles of BBDC Members Primarily Involved In Diabetes Research

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Woodgett, James

University of Toronto Appointment(s): Department of Medical Biophysics

Other Appointment(s): Director, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 

Contact Information:

Samuel Lunenfeld Research Institute
Mount Sinai Hospital
600 University Avenue, Room 982
Toronto, Ontario M5G 1X5

Phone: 416-586-8811
Fax: 416-586-8839
Email: woodgett@lunenfeld.ca
Websites: http://www.lunenfeld.ca/researchers/woodgett

Diabetes Related Research Activities:

Our laboratory is primarily interested in the abrogation of signal transduction pathways in human disease, in particular the phosphatidylinositol 3' kinase pathway and the Wnt pathway. Both are implicated in cancer and diabetes. We are studying several protein kinase components of these pathways, such as Protein Kinase B (PKB/Akt), Serum and Glucocorticoid-inducible Kinase 3 (SGK3) and Glycogen Synthase Kinase-3 (GSK-3). GSK-3 is associated with Alzheimer's Disease, bipolar disorder and type II diabetes. There are two mammalian genes for GSK-3, termed alpha and beta and we have generated both conventional and tissue-specific knockout mice strains of each. For example, we have generated mice that specifically lack GSK-3beta in either skeletal muscle and have characterized the insulin and glucose tolerances of these animals. GSK-3 is inhibited by insulin signalling and thus the knockouts are providing insight into the utility of GSK-3 inhibitors as sensitizers for insulin-resistant patients. We are also identifying novel targets for GSK-3 (and other protein kinases) which will help us understand the molecular mechanisms by which GSK-3 influences blood glucose responses.

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Wrana, Jeff - PhD

University of Toronto Appointment(s): Professor, Department of Molecular Genetics

Other Appointment(s): Senior Investigator, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
 

Contact Information:
LTRI, Rm. 1078
600 University Ave.
Toronto, ON   M5S 1X5

Phone: 416-586-4800 Ext. 2791
Email: wrana@lunenfeld.ca

Diabetes Related Research Activities:

Study of mechanisms underlying complications of diabetes, in particular kidney fibrosis.

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Wu, Xiao Yu (Shirley)

University of Toronto Appointment(s): Professor, Leslie Dan Faculty of Pharmacy

Other Appointment(s): Advanced Pharmaceutics & Drug Delivery Laboratory
 

Contact Information:

University of Toronto
Leslie Dan Pharmacy Building, Room 1103
144 College Street
Toronto, Ontario
M5S 3M2

Phone: 416-978-5272
Fax: 416-978-8511
Email: xywu@phm.utoronto.ca
Websites: http://www.pharmacy.utoronto.ca/users/wu-s

Diabetes Related Research Activities:

Advanced pharmaceutics and drug delivery. Our research interests and activities related to diabetes treatment include microencapsulation of enzymes, therapeutic hormones and polypeptides; artificial islet cells; nanomaterials such as bio-inorganic, polymer-metal and polymer-lipid hybrid nanoparticles and nanocomposite membranes; nanoparticulate contrast agents and fluorophores for in vitro/in vivo imaging; ROS-regulating systems; "intelligent" drug delivery systems for self-regulated drug delivery; nanotechnology-enabled glucose-responsive closed-loop insulin delivery implants for diabetic research animals and for clinical treatment.

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Yip, Christopher M. - PhD, PEng, FAAAS

University of Toronto Appointment(s): Associate Professor, Department of Chemical Engineering and Applied Chemistry; Department of Biochemistry; Institute of Biomaterials and Biomedical Engineering

Contact Information:

404–164 College Street
Toronto, Ontario, M5S 3G9

Phone: 416-978-7853
Fax: 416-978-4317
Email: christopher.yip@utoronto.ca
Websites: http://bigten.med.utoronto.ca

Diabetes Related Research Activities:

Our primary focus is in single molecule biophysics and specifically the interaction between biomolecules, including membrane receptors. Our primary research tools are single molecule microscopies (confocal / TIRF / atomic force) coupled with high-resolution infrared and fluorescence spectroscopies. We are motivated by a keen interest in the functional integration of these techniques to enable single molecule imaging in live cells. Our past efforts have included direct imaging of isolated insulin receptors in model membranes, single molecule force spectroscopy of insulin self-association, and mapping of glucacon fibril formation, and characterization of insulin crystallization by atomic force microscopy.

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Yu, Catherine

University of Toronto Appointment(s): Assistant Professor, Faculty of Medicine and Dalla Lana School of Public Health

Other Appointment(s): Staff, Division of Endocrinology & Metabolism, St. Michael's Hospital
Adjunct Scientist, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital

Contact Information:

61 Queen Street East
Toronto, Ontario M5C 2T2


Email: yuca@smh.ca
Websites: http://stmichaelshospitalresearch.ca/researchers/catherine-yu/

Diabetes Related Research Activities:

My research interests lie in the role of patient and clinician behaviour change in knowledge translation. I am particularly interested in the development of innovative strategies for continuing professional development and patient education in chronic disease management, specifically diabetes care.

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