Profiles of BBDC Members Primarily Involved In Diabetes Research

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Sun, Hong-Shuo - MD, MSc, PhD

University of Toronto Appointment(s): Associate Professor, PhD Supervisor
Department of Surgery, Division of Anatomy; Institute of Medical Science; Department of Physiology; Department of Pharmacology and Toxicology; Heart and Stroke Richard Lewar Centre of Excellence; Collaborative Program in Neuroscience (CPIN); Cardiovascular Sciences Collaborative Program (CSCP); Faculty of Medicine, University of Toronto

Contact Information:
Medical Sciences Building
1 King's College Circle
Toronto, ON   M5S 1A8

Phone: (416) 946-5506
Email: hss.sun@utoronto.ca

Diabetes Related Research Activities:

Research interest is in studying the role of ion channels (K(ATP) and TRPM2, etc.) in diabetes and stroke in diabetes, neuroprotection, and drug development, using in-vivo animal models of human diseases in combination with genomic analyses, advanced imaging, electrophysiology, and functional and behavioral assessments.

Publication related to diabetes research: Cerebrovascular safety of sulfonylureas: the role of K(ATP) channels in neuroprotection and the risk of stroke in patients with type 2 diabetes. Diabetes. 2016, 65(9): 2795-2809

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Sung, Hoon-Ki - MD, PhD

University of Toronto Appointment(s): Assistant Professor, Department of Laboratory Medicine and Pathobiology

Other Appointment(s): Scientist, Physiology & Experimental Medicine, Hospital For Sick Children

Contact Information:
Peter Gilgan Centre for Research and Learning
686 Bay Street, Room 10.9710
Toronto, ON   M5G 0A4

Phone: (416) 813-7654
Email: hoon-ki.sung@sickkids.ca
Websites: http://www.sickkids.ca/AboutSickKids/Directory/People/S/Hong-Ki%20Sung%20Staff%20Profile.html

Diabetes Related Research Activities:

My lab is studying Obesity, Metabolism and Diabetes at The Hospital for Sick Children. Our research focus includes:
1) patho-physiology of adipose tissue expansion and its causal role in metabolic defect and diabetes
2) identification of adipocyte precursor cells and its metabolic function by using mouse model

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Swardfager, Walter - PhD

University of Toronto Appointment(s): Assistant Professor, Department of Pharmacology & Toxicology, and School of Graduate Studies

Other Appointment(s): Scientist, Sunnybrook Research Institute

Contact Information:
Sunnybrook Health Science Centre
2075 Bayview Avenue, M6 174
Toronto, ON   M4N 3M5

Phone: (416) 836-0343
Email: w.swardfager@utoronto.ca
Websites: https://sunnybrook.ca/research/team/member.asp?m=688&t=13

Diabetes Related Research Activities:

My research examines neuroendorcrine contributions to mood and cognitive symptoms in type 2 diabetes. My lab conducts clinial studies, primarily of people with type 2 diabetes undertaking exercise-based rehabilitation and education interventions. We have a particular interest in the roles of cerebrovascular disease (including stroke and microagniopathy) in the effects of type 2 diabetes on the brain. We use neuroimaging, metabolomic and neurocognitive techniques.

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van der Kooy, Derek - PhD

University of Toronto Appointment(s): Professor, Department of Molecular Genetics

Contact Information:
Terrence Donnelly Centre for Cellular and Biomolecular Research
160 College Street, Room 1102
Toronto, ON   M5S 3E1

Phone: (416) 978-1960
Fax: (416) 978-2666
Email: derek.van.der.kooy@utoronto.ca
Websites: http://sites.utoronto.ca/nbrg/

Diabetes Related Research Activities:

The search for putative precursor cells within the pancreas has been a focus of extensive research. Adult mouse Pancreas-derived Multipotent Precursor (PMP) cells, possessing the intriguing capacity to generate cross-germ layer progeny in the pancreatic and neural lineages, have been identified. Here, genetic lineage-labelling was used to exclude the neural crest as the developmental source of PMPs. Notably, we demonstrate that the PMP cell expresses insulin in vivo, providing reconciliation with reports that new adult b cells are formed exclusively by self-replication. Further, PMP cells were shown to exist within adult human islet tissue, each capable of extensive proliferation, self-renewal, and generation of multiple differentiated pancreatic and neural cell types. Finally, the newly generated human b cell progeny were found to display regulated insulin secretion. These findings demonstrate that the adult mammalian pancreas contains a population of insulin+ multipotent stem cells, capable of contributing to the neural and pancreatic lineages.

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Verma, Subodh - MD, PhD, FRCSC

University of Toronto Appointment(s): Professor of Surgery
Professor of Pharmacology and Toxicology
 

Other Appointment(s): Staff Cardciac Surgeon, St. Michael's Hospital
Chair, CardioLink Clinical Trials Platform, St. Michael's Hospital
Member, Ryerson University-St Michael’s Hospital, Institute for Biomedical Engineering and Science Technology (iBEST)

Contact Information:
St. Michael's Hospital
30 Bond Street
Toronto, ON   M5B 1W8

Phone: (416) 864-5997
Email: vermasu@smh.ca

Diabetes Related Research Activities:

My research program focuses on cardiometabolic disease and diabetes-related co-morbidities.  As the Chair of the CardioLink Clinical Trials platform, I am conducting a number of clinical trials in diabetes and its complications.  The first of these trials, EMPA-Heart, seeks to uncover the mechanism underlying the cardioprotective effects of the SGLT2 inhibitor, empagliflozin, that was reported in the EMPA-REG Outcome study.  This trial is in the late stages of recruitment and will report primary outcomes in 2018. The NEWTON CABG trial will assess whether blockade of the PCSK9 receptor in individuals will diabetes can reduce the risk of future cardiac events after bypass surgery.  In the ENABLE-Chiropody trial, persons with diabetes undergoing hemodialysis will undergo a chiropody-based intensive, structured, and evidence-based care program with the aim of lowering the incidence and progression of diabetic foot ulcers and amputations.  This initiative is fully supported by a partnership with Diabetes Action Canada which is part of the CIHR-SPOR network.  In addition, I oversee a dynamic research lab in the Li Ka Shing Knowledge Institute of St. Michael's Hospital which has a special interest in the role of SGLT2 inhibitors as a potential modulator of endothelial function and atherosclerotic vascular disease.  Finally, I am a national lead/steering committee member on three SGLT2 inhibitor trials that are evaluating the impact of this class of drugs on heart failure.

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