Profiles of BBDC Members Primarily Involved In Diabetes Research

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Rosella, Laura - PhD, MHSc

University of Toronto Appointment(s): Assistant Professor, Dalla Lana School of Public Health

Other Appointment(s): Scientist, Public Health Ontario | Santé publique Ontario
Adjunct Scientist, Institute for Clinical Evaluative Sciences (ICES)

Contact Information:
Room 672
155 College Street
Toronto, ON   M5T 3M7

Phone: (416) 978-6064
Fax: (416) 978-1883
Email: laura.rosella@utoronto.ca
Websites: http://www.dlsph.utoronto.ca/faculty-profile/laura-c-rosella

Diabetes Related Research Activities:

The goal of my research is to inform the prevention of type 2 diabetes in the population. My research is focused on the use of advanced epidemiologic & biostatical approaches on large population-based data to inform public health activities targeted at reducing type 2 diabetes and obesity. I specialize on the development of population risk tools and have led methodological advances in the new field of risk algorithms applied to the population setting. I recently led the development of the Diabetes Population Risk Tool (DPoRT), which is the only existing only tool built to inform population intervention strategies for diabetes. This work is recognized as a novel way to inform to diabetes preventions strategies and is currently being used by policymakers in Canada. I have also led the largest study estimating diabetes-attributale health care costs as well as the burden of undiagnosed diabetes in Canada.

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Rozakis Adcock, Maria

University of Toronto Appointment(s): Associate Professor, Department of Laboratory Medicine & Pathobiology

Other Appointment(s):  
 
 

Contact Information:
Medical Sciences Building, Room 6238
1 King's College Circle
Toronto, ON   M5S 1A8

Phone: (416) 946-0392
Fax: (416) 978-5959
Email: maria.rozakis@utoronto.ca

Diabetes Related Research Activities:

The prevalence of obesity is increasing worldwide, as is the prevalence of obesity-related co-morbidity. Obesity is associated with an increased risk of developing insulin resistance and Type II diabetes (T2D). A universal observation in both humans and rodents is that impaired insulin secretion in is caused by a marked increase in pancreatic β-cell destruction that outweighs the rate of β-cell replication and renewal. Currently, the factors that instigate an increased rate of β-cell death during the pathogenesis of T2D are not fully understood. Research in the Rozakis lab is focused on understanding molecular and cellular processes that contribute to insulin resistance and Type II diabetes. Our lab has identified novel transcriptional networks that serve to regulate pancreatic islet regeneration and glucose homeostasis. We use a combination of biochemical, proteomic approaches and transgenic animal models to understand the molecular circuitry involved in transducing the unique actions of insulin on its target tissues.

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Scholey, James W. - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine

Other Appointment(s): Staff Physician (Nephrology), University Health Network and Mount SinaiHospital
 

Contact Information:
Toronto General Hospital
200 Elizabeth Street, Room 8N-859
Toronto, ON   M5G 2C4

Phone: (416) 340-5093
Fax: (416) 340-4999
Email: james.scholey@utoronto.ca

Diabetes Related Research Activities:

Research in my laboratory at the University of Toronto is focused on cellular and molecular mechanisms responsible for the development of diabetic nephropathy. In particular we study the role of the renin angiotensin system (RAS) in diabetic nephropathy and the link between the RAS, obesity, and activation of NADPH oxidase. We utilize transgenic mice in our approach and have combined whole animal studies with cell culture experiments to define cellular mechanisms of injury. We are currently studying mice with deletions in the genes for ACE2, p47, and adiponectin. Our laboratory also collaborates with investigators in the Human Physiology Laboratory at the University Health Network, Mount SinaiHospital, and the Hospital for Sick Children on studies of kidney function and urine proteomics in humans with diabetic nephropathy.

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Screaton, Robert - PhD

University of Toronto Appointment(s): Associate Professor, Department of Biochemistry

Other Appointment(s): Scientist, Sunnybrook Research Institute

Contact Information:
Sunnybrook Health Sciences Centre
2075 Bayview Avenue, Room M7 617
Toronto, ON   M4N 3M5

Phone: (416) 480-6100 ext. 5743
Email: robert.screaton@sri.utoronto.ca

Diabetes Related Research Activities:

My lab is interested in understanding how human cells respond to extracellular cues to maintain and ensure their function and survival. One central focus is to study how the pancreatic beta cell converts feeding cues into signals leading to insulin production and secretion. We use high-throughput functional screens to identify novel players involved in different cell-signaling pathways, including human pancreatic beta cell proliferation and those involved in the maintenance of mitochondria, critical subcellular organelles essential for cell function and survival. In addition to Type 1 and Type 2 diabetes, our work impacts upon cancer and neurodegeneration.

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Sefton, Michael

University of Toronto Appointment(s): Professor, Institute of Biomaterials and Biomedical Engineering

Contact Information:
Donnelly Centre for Cellular and Biomolecular Research
160 College St., Room 406
Toronto, ON   M5S 3E1

Phone: (416) 978-3088
Fax: (416) 978-4317
Email: michael.sefton@utoronto.ca
Websites: http://www.ibbme.utoronto.ca/faculty/members/sefton/

Diabetes Related Research Activities:

Biomaterials and tissue engineering: microencapsulation of mammalian cells including pancreatic islets; cell transplantation; immune and inflammatory responses to biomaterials; thrombogenicity of biomaterials.

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