Profiles of BBDC Members Primarily Involved In Diabetes Research

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Scholey, James W. - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine

Other Appointment(s): Staff Physician (Nephrology), University Health Network and Mount SinaiHospital
 

Contact Information:

Toronto General Hospital
200 Elizabeth Street, Room 8N-859
Toronto, Ontario M5G 2C4

Phone: 416-340-5093
Fax: 416-340-49999
Email: james.scholey@utoronto.ca

Diabetes Related Research Activities:

Research in my laboratory at the University of Toronto is focused on cellular and molecular mechanisms responsible for the development of diabetic nephropathy. In particular we study the role of the renin angiotensin system (RAS) in diabetic nephropathy and the link between the RAS, obesity, and activation of NADPH oxidase. We utilize transgenic mice in our approach and have combined whole animal studies with cell culture experiments to define cellular mechanisms of injury. We are currently studying mice with deletions in the genes for ACE2, p47, and adiponectin. Our laboratory also collaborates with investigators in the Human Physiology Laboratory at the University Health Network, Mount SinaiHospital, and the Hospital for Sick Children on studies of kidney function and urine proteomics in humans with diabetic nephropathy.

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Screaton, Robert - PhD

University of Toronto Appointment(s): Associate Professor, Department of Biochemistry

Other Appointment(s): Scientist, Sunnybrook Research Institute

Contact Information:

Sunnybrook Health Sciences Centre
2075 Bayview Avenue
Room M7 617
Toronto, Ontario
M4N 3M5

Phone: 416-480-6100 ext. 5743
Email: robert.screaton@sri.utoronto.ca

Diabetes Related Research Activities:

My lab is interested in understanding how human cells respond to extracellular cues to maintain and ensure their function and survival. One central focus is to study how the pancreatic beta cell converts feeding cues into signals leading to insulin production and secretion. We use high-throughput functional screens to identify novel players involved in different cell-signaling pathways, including human pancreatic beta cell proliferation and those involved in the maintenance of mitochondria, critical subcellular organelles essential for cell function and survival. In addition to Type 1 and Type 2 diabetes, our work impacts upon cancer and neurodegeneration.

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Sefton, Michael

University of Toronto Appointment(s): Professor, Institute of Biomaterials and Biomedical Engineering

Contact Information:

University of Toronto
Donnelly Centre for Cellular and Biomolecular Research
160 College St.
Room 406
Toronto, Ontario M5S 3E1

Phone: 416-978-3088
Fax: 416-978-4317
Email: michael.sefton@utoronto.ca
Websites: http://www.ibbme.utoronto.ca/faculty/members/sefton/

Diabetes Related Research Activities:

Biomaterials and tissue engineering: microencapsulation of mammalian cells including pancreatic islets; cell transplantation; immune and inflammatory responses to biomaterials; thrombogenicity of biomaterials.

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Shah, Baiju - MD, PhD, FRCPC

University of Toronto Appointment(s): Associate Professor, Department of Medicine
Associate Professor, Institute for Health Policy, Management and Evaluation

Other Appointment(s): Staff Endocrinologist, Sunnybrook Health Sciences Centre
Senior Scientist, Institute for Clinical Evaluative Sciences
Scientist, Sunnybrook Research Institute

Contact Information:

Institute for Clinical Evaluative Sciences
2075 Bayview Avenue, Suite G106
Toronto, Ontario M4N 3M5

Phone: 416-480-4706
Fax: 416-480-6048
Email: baiju.shah@ices.on.ca

Diabetes Related Research Activities:

My research focus is on the quality of and outcomes of diabetes care. Much of this work is done using linkage of large health care administrative data bases. My three main areas of interest are: a) the influence of different care models on diabetes quality and outcomes, b) gestational diabetes care and outcomes, and c) diabetes in vulnerable populations, including ethnic, immigrant and aboriginal communities.

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Shulman, Rayzel - MD, PhD

University of Toronto Appointment(s): Assistant Professor, Department of Pediatrics

Other Appointment(s): Staff Physician, Endocrinology, The Hospital For Sick Children
Fellow, Institute for Clinical and Evaluative Sciences (ICES)

Contact Information:
The Hospital for Sick Children
555 University Ave.
Toronto, ON   M5G 1X8

Phone: (416) 813-6218
Fax: (416) 813-6218
Email: rayzel.shulman@sickkids.ca

Diabetes Related Research Activities:

Health services and policy research related to diabetes care for children and young people.

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