Profiles of BBDC Members Primarily Involved In Diabetes Research

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Perkins, Bruce - MD

University of Toronto Appointment(s): Assistant Professor, Department of Medicine, Division of Endocrinology and Metabolism

Other Appointment(s): Staff Physician, University Health Network

Contact Information:

Leadership Sinai Centre for Diabetes
Mount Sinai Hospital
Room L5-210
60 Murray Street
Toronto, ON  M5T 3L9

Phone: (416) 586-8763
Email: bperkins@mtsinai.on.ca

Diabetes Related Research Activities:

My research initiatives focus on using epidemiological techniques to explore the natural history of diabetes complications and novel strategies for their prevention. My major clinical research areas include:
Characterizing the natural history of diabetic polyneuropathy and defining the best methods for clinical assessment.
Exploring the pattern of renal function decline and its determinants early in the course of nephropathy in type 1 diabetes.
Diabetes technologies, including the process of care for intensive insulin therapy.

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Philpott, Dana - PhD

University of Toronto Appointment(s): Associate Professor, Faculty of Medicine, Department of Immunology

Contact Information:
Medical Sciences Building, Room 7318
1 King's College Circle
Toronto, ON   M5S 1A8

Phone: (416) 978-7527
Email: dana.philpott@utoronto.ca

Diabetes Related Research Activities:

We are interested in the role of innate immunity, specifically Nod like receptors, as well as the microbiota in diabetes pathogenesis.

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Poussier, Philippe - MD

University of Toronto Appointment(s): Associate Professor, Department of Medicine, Division of Endocrinology and Metabolism, and Department of Immunology

Other Appointment(s):  
 
 

Contact Information:

Sunnybrook Health Science Centre Research Institute
2075 Bayview Avenue, Room A3.38
Toronto, Ontario M4N 3M5

Phone: 416-480-6136
Fax: 416-480-4375
Email: philippe.poussier@sri.utoronto.ca
Websites: http://sunnybrook.ca/research/team/member.asp?t=12&m=131&page=172

Diabetes Related Research Activities:

The objective of our research program is to identify type 1 diabetes (T1D) susceptibility genes in the spontaneously diabetic BB rat, and to characterize the immune mechanisms underlying allelic variation at these susceptibility loci. In particular, we are focusing on genes that appear to be shared between humans and the BB rat. These genetic studies combine linkage analyses, development and characterization of congenic and mutant lines of animals, transfected cell lines. We are also studying the role of differential colonization of the intestine by commensal bacteria on the development of antipancreatic autoimmunity with the objective to understand how environmental changes can affect the expression of diabetogenic genotypes. Another topic of research using transgenic murine models of type 1 diabetes is the characterization of the molecular mechanisms involved in the homing of diabetogenic T cells to pancreatic islets.

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Prud'homme, Gérald J. - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Laboratory Medicine and Pathobiology

Other Appointment(s): Clinician-Scientist, St. Michael's Hospital

Contact Information:

St. Michael's Hospital
Department of Laboratory Medicine
30 Bond St.
Toronto, ON M5B1W8

Phone: 416-864-6060 Ext: 3147
Email: prudhommeg@smh.ca
Websites: http://stmichaelshospitalresearch.ca/researchers/gerald-j-prudhomme/

Diabetes Related Research Activities:

Research in my laboratory focuses on the immunology of type 1 diabetes, and the development of new drugs and therapies for diabetes. We are studying some key molecules involved in immunopathological diseases, including transforming growth factor beta, neuropilin and the aryl hydrocarbon receptor. This work requires the application of a wide variety of immunological, molecular biological and biochemical techniques, in relevant disease models.

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Retnakaran, Ravi - MD, FRCPC

University of Toronto Appointment(s): Associate Professor, Department of Medicine, Division of Endocrinology and Metabolism

Other Appointment(s):  
 
 

Contact Information:
60 Murray Street, Suite L5-025, Mailbox 21
Toronto, ON   M5T3L9

Phone: 416-586-4800 ext 3941
Fax: 416-586-8853
Email: rretnakaran@mtsinai.on.ca

Diabetes Related Research Activities:

My research focuses on the early pathophysiology of type 2 diabetes (T2DM) and cardiovascular disease (CVD). A central component of this program is a large prospective observational cohort study of women recruited in pregnancy and followed longitudinally for several years postpartum. The concept underlying this program is that the gluco-regulatory response to the metabolic challenge posed by pregnancy provides unique physiologic insight into a woman's future risk of metabolic and vascular disease. Indeed, in a series of papers, we have demonstrated that a woman's glucose tolerance status in pregnancy provides a window to her future risk of both T2DM and CVD, ranging from high risk (in women with gestational diabetes (GDM)) to intermediate risk (in women with mild abnormalities of glucose tolerance in pregnancy) to low risk (in women that maintain normal antepartum glucose homeostasis). Thus, longitudinal cardio-metabolic characterization of a cohort of women reflecting the full spectrum of glucose tolerance in pregnancy can provide insight into early events in the pathophysiology of T2DM and CVD. The other main element of our research program is a series of clinical trials aimed at preservation of pancreatic beta-cell function early in the course of T2DM.

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