Profiles of BBDC Members Primarily Involved In Diabetes Research

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Nathan, Paul C. - MD, MSc

University of Toronto Appointment(s): Associate Professor, Department of Paediatrics, Division of Haematology/Oncology

Other Appointment(s): Associate Scientist, Hospital for Sick Children Research Institute

Contact Information:

The Hospital for Sick Children
555 University Avenue
Toronto, Ontario M5G 1X8

Phone: 416-813-8795
Fax: 416-813-5327
Email: paul.nathan@sickkids.ca
Websites: http://www.sickkids.ca/AboutSickKids/Directory/People/N/Paul-Nathan.html

Diabetes Related Research Activities:

Dr. Nathan's research focuses on long-term outcomes in survivors of childhood cancer. His interests include obesity and other metabolic sequelae of cancer treatment, as well as cardiac outcomes in children treated with cardiotoxic chemotherapy or radiation. In addition, he is interested in health care utilization and screening/surveillance late effects in adult survivors of childhood cancer.

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Ng, Dominic S. - PhD, MD, FRCPC

University of Toronto Appointment(s): AssociateProfessor, Department of Medicine, Division of Endocrinology & Metabolism; Department of Physiology and Department of Laboratory Medicine and Pathobiology

Other Appointment(s): Scientist, Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael's Hospital

Contact Information:

St. Michael's Hospital
30 Bond Street
Shuter Wing, 3rd Floor, Room 3-041
Toronto, Ontario M5B 1W8

Phone: 416-864-5197
Fax: 416-864-5584
Email: ngd@smh.ca

Diabetes Related Research Activities:

My research lab is primarily interested in the area of genetics of lipid disorders and cardio-metabolic disorders with special emphasis on high density lipoprotein (HDL) metabolism. We use transgenic/knock out mice as models and our tools include in vivo experiments, ex vivo and in vitro assays at tissue, cellular, and molecular levels. We are particularly interested in using in vivo mouse models to examine the impact of specific genetic-based dyslipidemic states on atherogenesis, diabetogenesis and more recently, obesity and brown fat development. Detailed analyses of these animal models using cellular, molecular and genetic markers will also be carried out to elucidate the underlying mechanism of such disease processes and their interactions. Such genetic models are also used to study the effects of dietary and drug interventions.

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Nostro, Maria Cristina - PhD

University of Toronto Appointment(s): Assistant Professor, Department of Physiology

Other Appointment(s): Harry Rosen Chair in Diabetes and Regenerative Medicine Research, McEwen Centre for Regenerative Medicine
Scientist, Division of Experimental Therapeutics, Toronto General Research Institute, UHN

Contact Information:
TMDT, Room 3-918
101 College St
Toronto, ON   M5G 1L7

Phone: 416-581-7595
Fax: 416-581-7606
Email: cnostro@uhnresearch.ca
Websites: http://www.uhnresearch.ca/researchers/profile.php?lookup=18710

Diabetes Related Research Activities:

- Generation of pancreatic beta cells from human pluripotent stem cells
- Cell therapy for type I diabetes
- Modeling lineage commitment and human development in vitro
- Using human pluripotent stem cell-derived pancreatic cells as a platform for drug screening

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Nunes Vasconcelos, Sara - PhD

University of Toronto Appointment(s): Assistant Professor, Institute of Biomaterials and Biomedical Engineering
Laboratory of Medicine and Pathobiology

Other Appointment(s): Assistant Scientist, Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network
Member of the Heart & Stroke/Richard Lewar Centre of Excellence (HSRLCE), University of Toronto
Member of Ontario Institute for Regenerative Medicine (OIRM)

Contact Information:
101 College St.
Toronto, ON   M5G 1L7

Phone: (416) 581-7527
Email: sara.vasconcelos@utoronto.ca

Diabetes Related Research Activities:

We are investigating how diabetes affects vessel formation (angiogenesis and arterio-venous specification) and its implications in tissue engineering for regenerative medicine. Moreover, we are investigating the direct effects of diabetes and diabetes-related drugs on crdiovascular health including human stem cell-derived cardiomyocyte organoid models.

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Ohashi, Pamela S. - PhD, FRSC

University of Toronto Appointment(s): Professor, Departments of Medical Biophysics and Immunology

Other Appointment(s): Director, Immune Therapy Program; Co-Director, Campbell Family Institute for Breast Cancer Research; Senior Scientist, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network

Contact Information:
620 University Ave.,
Toronto, ON   M5G 2C1

Phone: 416-946-2357
Fax: 416-204-2276
Email: pohashi@uhnresearch.ca

Diabetes Related Research Activities:

The major focus of my lab is to understand the mechanisms of death and differentiation in immature and mature T cells. In particular, an emphasis is placed on understanding the molecular events that direct T cell fate towards either tolerance or activation. These questions are investigated in the context of understanding autoimmunity (diabetes) and tumor immune surveillance in vivo.

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