Profiles of BBDC Members Primarily Involved In Diabetes Research

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Leong-Poi, Howard - MD, FRCPC, FASE

University of Toronto Appointment(s): Associate Professor of Medicine

Other Appointment(s): Clinician Scientist in the Keenan Research Centre at the Li Ka Shing Knowledge Institute
Head, Division of Cardiology, St. Michael's Hospital
Brazilian Ball Research Chair in Cardiology

Contact Information:
St. Michael's Hospital
30 Bond Street, 6-044 Queen Wing
Toronto, ON   M5B 1W8

Phone: (416) 864-5642
Fax: (416) 864-5989
Email: leong-poih@smh.ca

Diabetes Related Research Activities:

Research interests focus in several key areas:
1)  Contrast-enhanced ultrasound perfusion

2)  Molecular imaging using contrast-enhanced ultrasound and site-targeted microbubbles, in particular to track stem cell therapies.

3)  Small animal echocardiographic imaging of cardiac function

4)  Ultrasound-mediated gene delivery for ischemic cardiovascular disease, for heart failure and diabetic cardiomyopathy, and for anti-tumour therapies.

5)  Stem and progenitor cell therapies for ischemic cardiovascular disease, diabetic cardiomyopathy and heart failure.

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Lewis, Gary - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine; and Department of Physiology
Director, Banting & Best Diabetes Centre
Sun Life Financial Chair in Diabetes
Drucker Family Chair in Diabetes Research

Contact Information:
Toronto General Hospital
200 Elizabeth St., Eaton Building, Room 12E244
Toronto, ON   M5G 2C4

Phone: Office: (416) 340-4270 Lab: (416) 581-7487
Fax: (416) 340-3314
Email: gary.lewis@uhn.ca

Diabetes Related Research Activities:

The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, HDL lowering and hypertriglyceridemia.  We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction.  Previously we have performed both animal and human mechanistic studies but currently are focusing exclusively on the human.  In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states.  In our current CIHR-funded work we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and Type 2 diabetes.  We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.

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Lipscombe, Lorraine L. - MD, MSc, FRCPC

University of Toronto Appointment(s): Assistant Professor, Department of Medicine; Department of Health Policy, Management and Evaluation

Other Appointment(s): Research Scientist, Women's College Research Institute
Adjunct Scientist, Institute for Clinical Evaluative Sciences (ICES)
Staff Physician, Department of Medicine, Division of Endocrinology and Metabolism, Women's College Hospital

Contact Information:
Women's College Research Institute
741 – 790 Bay Street
Toronto, ON   M5G 1N8

Phone: (416) 351-3732 Ext: 3701
Fax: (416) 351-3746
Email: lorraine.lipscombe@wchospital.ca
Websites: http://www.womensresearch.ca/researchers/core-faculty/lorraine-lipscombe-md-msc-frcpc

Diabetes Related Research Activities:

Dr. Lipscombe's research program is aimed at improving the care and outcomes of persons living with diabetes with a particular focus on women, and targeting special female populations at higher risk for diabetes who would benefit from more focused diabetes prevention strategies. Her specific priority areas of interest include the association between breast cancer and diabetes, pregnancy planning in women with diabetes, post-partum diabetes risk and prevention in women with gestational diabetes, and drug safety in seniors with diabetes.

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Lowe, Julia - MB.ChBFRCP (UK) M.Med.Sci

University of Toronto Appointment(s): Associate Professor, Department of Medicine, Division of Endocrinology & Metabolism

Contact Information:
Sunnybrook Health Sciences Centre
2075 Bayview Avenue, Room H145
Toronto, ON   M4N 3M5

Phone: (416) 480-6948
Fax: (416) 480-4250
Email: julia.lowe@sunnybrook.ca

Diabetes Related Research Activities:

I received broad training as a specialist general internal physician, as well as specialty training in endocrinology in the UK. After completing this I went to Australia where I worked 25 years, first in community practice and then as a staff physician at John Hunter Hospital one of the teaching hospitals for Newcastle Medical school. I have a Masters in clinical epidemiology. For 4 years I was the Area Director of Diabetes for the Hunter region of NSW. My research interests are in chronic diabetes in pregnancy and health care delivery for diabetes. My research projects included the HAPO study and the Australian Longitudinal Study in Women's health, and a survey of Australian women with gestational diabetes. I also have funding for research into the epidemiology and use of health services by women with diabetes, and follow up of people who have attended diabetes and prediabetes education programmes in the Hunter and to redesign the service provided for young people with Type 1 diabetes in rural areas. In January 2008 I started work at the University of Toronto where I hold the rank of Associate Professor. Since coming to Toronto I have started a research programme on the management of diabetes in hospital inpatients and collaborated with colleagues in research on diabetes in pregnancy as well as continuing my Australian research.

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Luk, Cynthia - MD, PhD

University of Toronto Appointment(s): Assistant Professor, Department of Medicine, University of Toronto

Other Appointment(s): Staff Physician, Division of Endocrinology and Metabolism, Department of Medicine, St. Michael's Hospital

Contact Information:
Li Ka Shing Knowledge Institute
209 Victoria Street
Toronto, ON   M5B 1T8

Phone: (416) 864-6060
Email: c.luk@utoronto.ca

Diabetes Related Research Activities:

Obesity is the strongest risk factor for type 2 diabetes but many people with diabetes are not obese.  Dr. Luk’s research focuses on identifying the signaling pathways linking obesity and diabetes, and determining the role of adipose tissue in metabolic syndrome.

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