Profiles of BBDC Members Primarily Involved In Diabetes Research
Irwin, David M. - PhD
University of Toronto Appointment(s): Professor, Department of Laboratory Medicine and Pathobiology
Medical Sciences Building room 6211
1 King's College Circle
Toronto, ON M5S 1A8
Diabetes Related Research Activities:
Research in the Irwin lab focuses on the evolution of genes involved in diabetes. Many of the genes and proteins (e.g., the proglucagon-derived peptides glucagon, GLP-1, and GLP-2) involved in glucose metabolism are related yet have differing function. By examining the origin and evolution of these genes we hope to identify portions of the sequences important for their unique functions. We are also interested in role of liver-specific glucokinase in glucose metabolism. We are currently using comparative and molecular approaches to identify regulatory sequences essential for regulation of expression, including insulin induction, of the glucokinase gene in the liver.