Profiles of BBDC Members Primarily Involved In Diabetes Research

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Fantus, I. George - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine; and Department of Physiology
Associate Dean, Research, Faculty of Medicine

Other Appointment(s): Senior Scientist, Toronto General Research Institute
Associate Scientist, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Staff Endocrinologist, Mount Sinai Hospital and University Health Network
Member, Institute of medical Sciences
Member, School of Graduate Studies
 

Contact Information:
Lebovic Bldg. Room 5028
60 Murray St.
Toronto, ON   M5T3L9

Phone: 416-586-8665
Fax: 416-361-2657
Email: gfantus@mtsinai.on.ca

Diabetes Related Research Activities:

The major research focus of our lab is to define the mechanisms of insulin resistance at the cellular and molecular level.  The goal is to develop new approaches to treatment and prevention of insulin resistance.  Studies in insulin target tissues, adipocytes and muscle cells, rendered insulin resistant by metabolites, e.g. glucose and free fatty acids; cytokines, e.g TNF- a; and hormones, e.g. insulin and angiotension, are carried out to determine changes in enzyme activation, in protein-protein interactions and glucose transporter translocation. The lab is also conducting research to define the abnormalities of cell signaling caused by exposure to high glucose.  The goal here is to define the pathogenetic changes contributing to diabetic nephropathy. Studies in mesangial cells and podocytes and in diabetic rodent models are addressing novel mechanisms by which alterations in cell signaling by Src and oxidative stress cause high glucose-mediated changes which trigger diabetic nephropathy.

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Farkouh, Michael E. - MD, FRCPC, FACC, FAHA

University of Toronto Appointment(s): Director, Cardiology Research, Division of Cardiology; Associate Professor, Department of Medicine

Other Appointment(s): Director, Clinical Trials, Peter Munk Cardiac Centre, University Health Network
Scientist, Li Ka Shing Knowledge Institute, St. Michael's Hospital

Contact Information:

Peter Munk Cardiac Centre, University Health Network
585 University Avenue, Room 4N474
Toronto, Ontario M5G 2N2

Phone: 416-340-3141
Fax: 416-340-3398
Email: michael.farkouh@uhn.ca

Diabetes Related Research Activities:

Diabetes Mellitus and Cardiovascular Disease: The main focus is the evaluation of diabetic patients with coronary artery disease, acute coronary syndromes and heart failure. We have examined the role of advanced multi-modal imaging in developing novel compounds to treat atherosclerosis in diabetic patients. I have conducted large-scale clinical trials such as the FREEDOM Trial which evaluated the optimal strategy required for the management of coronary artery disease. Our goal for the future is to develop a collaborative coordinating center to address the important clinical questions revolving around diabetes and heart disease.

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Feig, Denice S. - MD, MSc, FRCPC

University of Toronto Appointment(s): Associate Professor, Departments of Medicine, Obstetrics & Gynecology, Health Policy, Management and Evaluation; Division of Endocrinology & Metabolism

Contact Information:

Mount Sinai Hospital
60 Murray St.,
Room 5027
Toronto, Ontario, M5T 3L9

Phone: 416-586-8590
Fax: 416-361-2657
Email: dfeig@mtsinai.on.ca

Diabetes Related Research Activities:

Main research interest is in the area of diabetes in pregnancy.
We are currently conducting a multi-centre randomized controlled trial of metformin use in women with type 2 diabetes in pregnancy (MiTy trial).
I am also involved in studies looking at the placental transfer of diabetes drugs in pregnancy, the transfer of diabetes drugs into breast milk, and administrative databases looking at women with diabetes in pregnancy in Ontario.

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Feng, Zhong-Ping - MD, PhD

University of Toronto Appointment(s): Professor, Department of Physiology; Director, Collaborative Program In Neuroscience, School of Graduate Studies

Contact Information:

Department of Physiology
University of Toronto
3306 MSB
1 King's College CircleToronto, ON M5S 1A8

Phone: 416-946-0671
Fax: 416-978-4373
Email: zp.feng@utoronto.ca
Websites: http://www.physiology.utoronto.ca/content/zhong-ping-feng

Diabetes Related Research Activities:

The Feng lab is interested in understanding the mechanisms underlying synapse development and synaptic transmission using various in vitro and in vivo animal models. The major lines of research in the Feng Lab include 1) identifying the roles of ion channels in neurons and pancreatic cells under physiological and pathophysiological conditions, 2) determining the regulatory mechanisms of the ion channels, and 3) understanding neuronal control of hormone secretion in control and diabetic rodent models. The technical expertise in the Feng lab includes patch-clamp recordings, dynamic ratiometric imaging, confocal imaging, molecular biology and biochemistry.

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Fish, Jason - PhD

University of Toronto Appointment(s): Associate Professor, Department of Laboratory Medicine & Pathobiology

Other Appointment(s): Senior Scientist, Toronto General Hospital Research Institute

Contact Information:
MaRS Discovery Tower East
101 College Street, 3-308
Toronto, ON   M5G 1L7

Phone: (416) 581-7496
Email: jason.fish@utoronto.ca
Websites: https://www.uhnresearch.ca/researcher/jason-fish

Diabetes Related Research Activities:

Our lab studies the role of microRNAs in controlling vascular inflammation. We have a particular interest in determining the role of circulating microRNAs in disease pathogenesis, and exploring their use as biomarkers. We are studying mouse models of diabetic cardiomyopathy to define disease mechanisms that involve microRNAs and we are identifying circulating microRNA biomarkers in human patient cohorts with diabetes, diabetic cardiomyopathy and/or end-stage renal disease.

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