Profiles of BBDC Members Primarily Involved In Diabetes Research

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Danska, Jayne

University of Toronto Appointment(s): Professor, Department of Immunology; Department of Medical Biophysics

Other Appointment(s): Program in Genetics and Genome Biology, Hospital for Sick Children

Contact Information:

MaRS, East Tower
101 College Street
Room 14-313
Toronto, Ontario M5G 1L7

Phone: 416-813-8810
Fax: 416-813-8823
Email: jayne.danska@sickkids.ca
Websites: http://www.sickkids.ca/Research/Danska-lab/index.html

Diabetes Related Research Activities:

The objective of our research program is to define the genetic and environmental factors driving autoimmune mediated targeting of islet cells and to use this information to design and test therapeutics that prevent, block progression of or reverse type 1 diabetes. We have taken a multidisciplinary approach to genetic, genomic and immunological analysis of T1D risk in a well-validated mouse models, focusing on dissection of the complex genetics to provide insight into human T1D pathogenesis. We have extended these studies of the role of sex and of intestinal commensal bacteria on modifying genetic risk, and application of discoveries in rodent models to large, prospective cohort study of environmental determinants of T1D in genetically at risk children.

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Dash, Satya - MD, PhD, FRCPC, MRCP(UK)

University of Toronto Appointment(s): Assistant Professor, Department of Medicine, Division of Endocrinology and Metabolism (effective Sept. 1, 2015)

Other Appointment(s): Staff Physician, University Health Network/Mount Sinai Hospital (effective Sept. 1, 2015)

Contact Information:

Toronto General Hospital
Eaton Building, 12EN
200 Elizabeth St.
Toronto, ON  M5G 2C4

Phone: pending
Email: satyad@uhnres.utoronto.ca

Diabetes Related Research Activities:

I am interested in obesity and insulin resistance. More specifically I aim to assess the role of the central nervous system in mediating various metabolic processes in humans in responses to drugs and peptides. Another avenue of research I will explore is investigating the etiology of obesity, its metabolic complications and response to treatment. I aim to utilize a combination of integrative in vivo physiology, genetic and pharmacological approaches to answer these research questions with the ultimate aim of potentially developing novel therapies for metabolic disorders.

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De Melo, Margaret - BSc, RD, CDE

University of Toronto Appointment(s):

Other Appointment(s): Practice Leader-Clinical Nutrition, Allied Health, University Health Network

Contact Information:
Toronto Western Hospital
399 Bathurst Street 1WW443
Toronto, ON   M5T 2S8

Phone: 416-603-5800 Ext: 5973
Fax: 416-603-5210
Email: margaret.demelo@uhn.ca

Diabetes Related Research Activities:

I am interested in research that focuses on diabetes self-care management (DSM).

As part of interprofessional research teams, I have studied the effectiveness of DSM education programs, utilization and attrition such programs, food insecurity in Canadians with diabetes, and gender differences, psychosocial and clinical factors that help us better understand and serve those affected by diabetes.

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Drucker, Daniel J. - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine, Division of Endocrinology & Metabolism

Other Appointment(s): Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Contact Information:
600 University Ave TCP5-1004
Toronto, ON   M5G1X5

Phone: 416-361-2661
Fax: 416-361-2669
Email: drucker@lunenfeld.ca
Websites: http://www.glucagon.com

Diabetes Related Research Activities:

Research in the Drucker lab is focused on understanding the biology of gut hormones, with a major focus on GIP and the glucagon-like peptides. The lab studies how glucagon, GIP, GLP-1, and GLP-2 regulate energy homeostasis, metabolic control, and cardiovascular function via effects on the gastrointestinal tract, pancreas, cardiovascular system and central nervous system. Specific projects elucidate novel mechanisms of glucagon, GIP, GLP-1 and GLP-2 action through studies of their respective receptors in peripheral tissues. Research staff utilize a combination of techniques that involve studies of signal transduction, generation of transgenic or knockout mice, and studies of rodent models of peptide hormone action with a focus on diabetes, obesity, endocrine systems, and intestinal disease.

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