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Scholey, James W. - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine

Other Appointment(s): Staff Physician (Nephrology), University Health Network and Mount SinaiHospital

Contact Information:

Toronto General Hospital
200 Elizabeth Street, Room 8N-859
Toronto, Ontario M5G 2C4

Phone: 416-340-5093
Fax: 416-340-49999

Diabetes Related Research Activities:

Research in my laboratory at the University of Toronto is focused on cellular and molecular mechanisms responsible for the development of diabetic nephropathy. In particular we study the role of the renin angiotensin system (RAS) in diabetic nephropathy and the link between the RAS, obesity, and activation of NADPH oxidase. We utilize transgenic mice in our approach and have combined whole animal studies with cell culture experiments to define cellular mechanisms of injury. We are currently studying mice with deletions in the genes for ACE2, p47, and adiponectin. Our laboratory also collaborates with investigators in the Human Physiology Laboratory at the University Health Network, Mount SinaiHospital, and the Hospital for Sick Children on studies of kidney function and urine proteomics in humans with diabetic nephropathy.

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