Member Profile Page
Floras, John S. - MD, DPhil, FRCPC, FACC, FAHA, FESC
University of Toronto Appointment(s): Professor, Division of Cardiology, Department of Medicine
Other Appointment(s): Research Director, University Health Network and Mount Sinai Hospital Division of Cardiology
Chair, Board of Trustees, Banting Research Foundation
Canada Research Chair in Integrative Cardiovascular Biology
Mount Sinai Hospital
600 University Avenue, Suite 1614
Diabetes Related Research Activities:
The general theme of the Floras Clinical Cardiovascular Physiology Laboratory has been the elucidation of mechanisms responsible for initiation and progression of cardiovascular and related diseases in humans, through interdisciplinary patient oriented research.
Neural and intrinsic cardiovascular regulation is studied using: microneurographic recordings of sympathetic nerve discharge directed at resistance vessels, tracer kinetic methods to estimate total body norepinephrine spillover, spectral analysis of heart rate variability and baroreflex sensitivity for heart rate, plethysmographic methods for assessing blood flow, and ultrasonic methods for quantifying endothelium dependent and independent vasodilatation.
These methods have been applied to research questions concerning normal health and aging, and to conditions such as heart failure, sleep apnea, hypertension, renal failure, pulmonary hypertension, diabetes (in collaboration with Drs. Zinman, Millar and Meneilly), menopause and cirrhosis.