Member Profile Page
Fantus, I. George - MD, FRCPC
University of Toronto Appointment(s): Professor, Department of Medicine; and Department of Physiology
Associate Dean, Research, Faculty of Medicine
Other Appointment(s): Senior Scientist, Toronto General Research Institute
Associate Scientist, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Staff Endocrinologist, Mount Sinai Hospital and University Health Network
Member, Institute of medical Sciences
Member, School of Graduate Studies
Lebovic Bldg. Room 5028
60 Murray St.
Toronto, ON M5T3L9
Diabetes Related Research Activities:
The major research focus of our lab is to define the mechanisms of insulin resistance at the cellular and molecular level. The goal is to develop new approaches to treatment and prevention of insulin resistance. Studies in insulin target tissues, adipocytes and muscle cells, rendered insulin resistant by metabolites, e.g. glucose and free fatty acids; cytokines, e.g TNF- a; and hormones, e.g. insulin and angiotension, are carried out to determine changes in enzyme activation, in protein-protein interactions and glucose transporter translocation. The lab is also conducting research to define the abnormalities of cell signaling caused by exposure to high glucose. The goal here is to define the pathogenetic changes contributing to diabetic nephropathy. Studies in mesangial cells and podocytes and in diabetic rodent models are addressing novel mechanisms by which alterations in cell signaling by Src and oxidative stress cause high glucose-mediated changes which trigger diabetic nephropathy.