Member Profile Page
Wheeler, Michael B. - PhD
University of Toronto Appointment(s): Professor, Departments of Medicine and Physiology
Other Appointment(s): Senior Scientist, Toronto General Hospital Research Institute, University Heath Network
University of Toronto
Medical Sciences Building, Room 3352
1 King's College Circle
Toronto, ON M5S 1A8
Diabetes Related Research Activities:
Our research is focussed on developing novel strategies to treat Type1 and Type 2 diabetes using multidisciplinary approaches, which combine information gained from genetic models of diabetes, genomics/proteomics, molecular biology and cell biology. Defects in pancreatic endocrine function are central factors in the pathology of diabetes. As such, we are currently investigating several avenues of research that explore pancreatic islet function in both healthy and diseased states. These include the role oxidative stress, reactive oxygen species and uncoupling proteins in the development of diabetes. We also explore the roles of membrane bound proteins like transporter, ion channels and receptors on pancreatic islet function. Another major thrust of our research is to work closely with stem cell biologists in Toronto to produce and characterize stem cell-derived beta cells for potential use in treating Type 1 diabetes.
Members of the Wheeler lab have access to state-of-art facilities at both the University of Toronto and the University Health Network at TMDT and have forged collaborations with world-class research teams working in the diabetes field. The laboratory is affiliated with the Endocrinology and Diabetes Research Group in the Department of Physiology at U of Toronto and the Banting and Best Diabetes Centre at UHN. As such the Wheeler lab is an excellent training environment for undergraduates, M.Sc. and Ph.D. candidate as well as post-doctoral fellows and residents interested in diabetes.