Member Profile Page
Retnakaran, Ravi - MD, FRCPC
University of Toronto Appointment(s): Associate Professor, Department of Medicine, Division of Endocrinology and Metabolism
60 Murray Street, Suite L5-025, Mailbox 21
Toronto, ON M5T3L9
Phone: 416-586-4800 ext 3941
Diabetes Related Research Activities:
My research focuses on the early pathophysiology of type 2 diabetes (T2DM) and cardiovascular disease (CVD). A central component of this program is a large prospective observational cohort study of women recruited in pregnancy and followed longitudinally for several years postpartum. The concept underlying this program is that the gluco-regulatory response to the metabolic challenge posed by pregnancy provides unique physiologic insight into a woman's future risk of metabolic and vascular disease. Indeed, in a series of papers, we have demonstrated that a woman's glucose tolerance status in pregnancy provides a window to her future risk of both T2DM and CVD, ranging from high risk (in women with gestational diabetes (GDM)) to intermediate risk (in women with mild abnormalities of glucose tolerance in pregnancy) to low risk (in women that maintain normal antepartum glucose homeostasis). Thus, longitudinal cardio-metabolic characterization of a cohort of women reflecting the full spectrum of glucose tolerance in pregnancy can provide insight into early events in the pathophysiology of T2DM and CVD. The other main element of our research program is a series of clinical trials aimed at preservation of pancreatic beta-cell function early in the course of T2DM.