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Lewis, Gary - MD, FRCPC

University of Toronto Appointment(s): Professor, Department of Medicine; and Department of Physiology
Director, Banting & Best Diabetes Centre
Sun Life Financial Chair in Diabetes
Drucker Family Chair in Diabetes Research

Contact Information:

Office:
Toronto General Hospital
200 Elizabeth St., Eaton Building, Room 12E244
Toronto, ON M5G 2C4

Lab:
MaRS Centre, Toronto Medical Discovery Tower
101 College St., Room 10-203
Toronto, ON M5G 1L7

Phone: Office: 416-340-4270 Lab: 416-581-7487
Fax: 416-340-3314
Email: gary.lewis@uhn.ca

Diabetes Related Research Activities:

The Lewis lab has had a long interest in the mechanisms of various aspects of diabetic dyslipidemia, including postprandial lipemia, HDL lowering and hypertriglyceridemia.  We have also had a long standing interest in the interaction between free fatty acids and pancreatic beta cell dysfunction.  Previously we have performed both animal and human mechanistic studies but currently are focusing exclusively on the human.  In 2002, working in close collaboration with Dr. Khosrow Adeli (U of T), we made the novel observation that the intestine, in addition to the liver, overproduces lipoproteins in insulin resistant states.  In our current CIHR-funded work we are determining the mechanism of intestinal and hepatic lipoprotein overproduction in insulin resistance and Type 2 diabetes.  We perform integrative, physiological studies in humans, attempting to determine the regulation of intestinal and hepatic lipoprotein particle production by hormones, nutrients and pharmacological agents.

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