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Cox, Brian - BSc, MSc, PhD

University of Toronto Appointment(s): Assistant Professor, Department of Physiology

Contact Information:

Department of Physiology
University of Toronto
1 King's College Circle
Medical Sciences Building, Room 3360 
Toronto, Ontario  M5S 1A8

Phone: Office: 416-978-3241 Lab: 416-978-3240

Diabetes Related Research Activities:

I have strong research interests in the area of fetal maternal health and developmental origins of disease. I have several manuscripts on the development of the placenta and trophoblast cell lineages and on hypertensive disorders of pregnancy, such as preeclampsia. My interest in diabetes is in gestational diabetes, often found in conjunction with preeclampsia and the acute and chronic affect on the child, relating to the increased risk of developing type II diabetes. I apply a systems biology approach involving the generation and integration of proteomics, transcriptional and epigenetic data sets. I apply computational models to identify different molecular disease classes and mechanisms of gene regulation. I have several papers on the inter species comparisons of human and mouse tissues and disease models to understand the similarities and develop improved disease models for research. I am proposing to work with animal models of gestational diabetes and compare these results to human samples from bio banked placental material of patients with gestational diabetes. My goal is to develop better bio markers to determine the likelihood of developing diabetes after pregnancy.

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